Current Issue : October-December Volume : 2011 Issue Number : 4 Articles : 4 Articles
Microencapsulation technique involves surrounding and enclosement of small discrete solid particles or small liquid droplets by an intact shell. It modifies and delays drug release from pharmaceutical dosage forms. Microencapsulation is a vital technique in novel drug delivery system and has a wide scope than conventional multi dose drug therapy. This article involves preperation, properties and uses of individually encapsulated novel small paticles....
In order to increase the retention time of the drug in the body, Floating Microsphere are used which provide the drug release for more than 12 hours. The main purpose of writing this review on floating drug delivery systems (FDDS) is to correlate and compile the recent literature on the principal mechanism and working of floatation to achieve gastric retention. In this article, Various techniques to design single-unit and multiple-unit floating systems with their classification, formulations and Evaluation aspects such as the Particle size determination and Buoyancy are elaborately discussed. The in vitro techniques and in vivo studies to evaluate the performance and application of floating systems are also mentioned. Floating drug delivery system, are useful for various problems encountered during the development of a pharmaceutical dosage form....
In the present study, spherical microbeads are able to prolong and control the release of nifedipin. were prepared by ionotropic gelation method, using sodium alginate as the hydrophilic carrier in combination with HPMC and sodium alginate as drug release modifiers in various proportions to overcome the drug related adverse effects, improve drug bioavailability in different GI tract conditions. Formulated microbeads were investigated for physicochemical properties and drug release potential. All investigated properties showed satisfactory results. While testing size distribution, flow properties and mean diameter of microbeads, there was no significant drug-polymer interactions were observed. The formulated floating alginate beads have shown higher percentage (28.11 % to 39.98 %) of drug loading, particle size (610.75 to 845.62 , higher release of drug. The Optical microscopy of floating alginate beads reveals that the beads are mainly spherical and the use of calcium carbonate, which provides floating property. In-vitro dissolution study showed that 90 % drug release, amongst the formulations, formulation 4 released Nifedipin for prolonged duration (12 hours). Formulated floating beads of Nifedipin showed good swelling behavior....
Poor water solubility often leads to low bioavailability due to low dissolution velocity. Isradipine a potent calcium channel blocker exhibits poor water solubility and thus have inadequate bioavailability. The objective of the present work was to develop and characterize solid nanoemulsion preconcentrate of Isradipine. For this a optimized liquid self-nanoemulsifying drug delivery system (SNEDDS) of Isradipine was formulated. The optimized liquid SNEDDS consist of Isradipine, Capmul MCM EP, Tween 80 and Polyethylene glycol 400 in the weight ratio of 1.64:9.82:44.27:44.27, produces SNEDDS with lower particle size 16.31nm, polydispersity index 0.19, and zeta potential -3.10. The optimized liquid SNEDDS formulation was converted into excellent free flowing solid nanoemulsion preconcentrate of Isradipine by adsorbing onto Neusilin UFL2® a solid carrier. The dissolution characteristics of solid nanoemulsion preconcentrate filled into hard gelatin capsules was investigated and compared with liquid SNEDDS formulation and pure drug to ascertain the impact on dissolution following conversion. The results indicated that solid nanoemulsion preconcentrate showed comparable rate and extent of drug dissolution in a dissolution medium as liquid SNEDDS but have higher dissolution than the pure drug. Thus, Solid Nanoemulsion Preconcentrate combines the advantages of liquid SNEDDS (i.e. enhanced solubility) with those of solid dosage form (e.g. low production cost, convenience of process control, high stability and reproducibility, better patient compliance). The results from this study demonstrates that solid nanoemulsion preconcentrate may be use as a means of improving solubility, dissolution, and ultimately the bioavailability of Isradipine....
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